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KMID : 0352519830200010009
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Korea Univercity Medical Journal
1983 Volume.20 No. 1 p.9 ~ p.20
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Effects of hypertonic NaCl and CaCl₂ administration upon urinary excretion of Na, K, Cl, Ca and PO₄ in thyroparathyroidectomized rabbits
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Woo Jong-Won
Choi Duck-Kyung
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Abstract
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This study was performed for the purpose of investigating the effect of intravenous administration of hypertonic NaCl and CaCl₂ solution upon urinary excretion of electrolytes in thyroparathyroidectomized(TPTX) rabbits.
Experimental animals were divided into 5 groups, namely: normal control group(N=18) ; acute TPTX group, 3 days after TPTX(N=14); chronic TPTX group, to 10 days after TPTX(N=11); NaCl group, 205 mEq/L NaCl solution was infused to chronic TPTX group (n=9); CaCl₂ group, 400mEq/L was infused(N=9), 800 mEq/L CaCl₂ solution was infused additionally(N=8).
When thyroparathyroids were taken away, synthyroids(0.2 ㎎/day) were administered to the rabbits for the maintenance of thyroid function. Hypertonic NaCl and CaCl₂ solutions were infused for an four by the rate of 0.8 ml/min. Serum and urinary electrolytes were measured before and after the infusion hypertonic solutions by the following methods: Na and K, flame photometry; Cl, Schales and Schales method; Ca, EDTA titration method and PO₄ by Fisk and SubbaRow method.
The Serum findings;
A. Serum findings;
1. Both in TPTX and NaCl group there were no significant changes in serum electrolytes concentration from those of control group.
2. In CaCl₂ group serum levels of Ca and Cl increased significantly, but serum PO₄ showed marked findings:
1. Urinary concentration of Na and Cl increased in both of NaCl and CaCl₂ group, more markedly in CaCl₂ group.
2. In TPTX group urinary K concentration increased but decreased in NaCl and CaCl₂ groups.
3. Urinary Ca decreased slightly In TPTX and NaCl groups, on the contrary in CaCl₂ group there was marked increase in urine Ca concentration.
4. TPTX group showed significant increase in PO₄ excretion, on the otherhand, NaCl and CaCl₂ groups showed marked decrease of them.
From the above results it was suggested that serum Ca concentration might affect membrane permeability and electrolytes transport across the renal tubular cells.
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